Home | MedChem Lab

Medicinal Chemistry Lab
University of Brescia

OUR RESEARCH

01 / DNA PROBING

02 / PDE INHIBITORS

03 / NATURAL COMPOUNDS AND CELL PATHWAYS

Computational studies pave the way for the design and synthesis of small molecules selectively targeting peculiar DNA and RNA arrangements, attractive targets in anticancer and antiviral drug design. In our research group, we take advantage of mass spectrometry to provide insights in the ligand-target interaction.

J. Med. Chem. Perspective paper

Ribaudo G, Ongaro A, Oselladore E, Memo M, Gianoncelli A. Combining Electrospray Mass Spectrometry (ESI-MS) and Computational Techniques in the Assessment of G-Quadruplex Ligands: A Hybrid Approach to Optimize Hit Discovery. J. Med. Chem. 2021

Read it HERE!

Since variations in cAMP and cGMP and/or nitric oxide levels interfere with downstream pathways involved in memory processes, the potential of phosphodiesterase (PDE) inhibitors in contrasting neurodegeneration emerges. Our group also investigates novel applications of PDE inhibitors.

New ACS Chem Neurosci paper

Landucci E, Ribaudo G, Anyanwu M, Oselladore E, Giannangeli M, Mazzantini C, Lana D, Giovannini MG, Memo M, Pellegrini-Giampietro DE, Gianoncelli A. Virtual Screening-Accelerated Discovery of a Phosphodiesterase 9 Inhibitor with Neuroprotective Effects in the Kainate Toxicity In Vitro Model. ACS Chem Neurosci. 2023

Read it HERE!

In the era of nature-inspired pharmacology, our expertise in the field of analytical chemistry is applied to natural compounds. In our laboratory, we develop extractive and analytical protocols to isolate and characterize small molecules of biological interest.

Guest edited Special Issue

"Natural Products Chemistry: Advances in Synthetic, Analytical and Bioactivity Studies" (Molecules)

Submissions to Volume II are now open, click HERE!

04 / ANALYTICAL CHEMISTRY

In our research group, we develop analytical methods based on techniques such as HPLC, mass spectrometry and NMR to characterize and quantify small organic compounds and macromolecules (proteins, nucleic acids), ranging from organic reaction monitoring to biological samples.

Product

PUBLICATIONS

Ribaudo G, Carotti M, Ongaro A, Oselladore E, Scano M, Zagotto G, Sandonà D, Gianoncelli A. Synthesis and Evaluation of Bithiazole Derivatives As Potential α-Sarcoglycan Correctors. ACS Med Chem Lett. 2023.

Ribaudo G, Yun X, Ongaro A, Oselladore E, Ng JPL, Haynes RK, Law BYK, Memo M, Wong VKW, Coghi P, Gianoncelli A. Combining computational and experimental evidence on the activity of antimalarial drugs on papain-like protease of SARS-CoV-2: A repurposing study. Chem Biol Drug Des. 2023.

Ongaro A, Desiderati G, Oselladore E, Auricchio D, Memo M, Ribaudo G, Sissi C, Gianoncelli A. Amino-Acid-Anthraquinone Click Chemistry Conjugates Selectively Target Human Telomeric G-Quadruplexes. ChemMedChem. 2022.

Ongaro A, Oselladore E, Memo M, Ribaudo G, Gianoncelli A. Insight into the LFA-1/SARS-CoV-2 Orf7a Complex by Protein–Protein Docking, Molecular Dynamics, and MM-GBSA Calculations. Journal of Chemical Information and Modeling. 2021.

Ribaudo G, Ongaro A, Zagotto G, Memo M, Gianoncelli A. Therapeutic Potential of Phosphodiesterase (PDE) Inhibitors Against Neurodegeneration: the Perspective of the Medicinal Chemist. ACS Chem. Neurosci. 2020